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To understand why screening matters, it helps to know how these drugs work

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The practical consequence is a slower required step-up than either mono- or dual-agonist regimens

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Microdosing starts at doses below the lowest commercially available starting dose and is titrated slowly to achieve neuromodulatory and metabolic effects without the full appetite suppression or side effects of standard dosing

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GLP-1based therapies deliver major benefits for glycemia, weight, and in some settings cardiovascular risk, she says

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