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A synthetic octapeptide (GGVLVQPG), named FZI/0 (92, 94), AT1001 (95, 96), and most recently larazotide (97, 98), corresponding to the amino acids 815 of this fragment, did not affect permeability, but pretreatment offered significant protection against the effect of subsequent treatment with purified Zot or zonulin (69, 92)