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First, it stimulates vascular endothelial growth factor expression
10.1016/j.mam.2009.01.001 Mol Asp Med
Less commonly recognized but still valid qualifying conditions include prediabetes (elevated fasting glucose or A1C between 5.7-6.4%), polycystic ovary syndrome, non-alcoholic fatty liver disease, osteoarthritis of weight-bearing joints, and chronic kidney disease
3.2 SPY001, SPY002, SPY003 A clinical trial investigating SPY001 SPY002, and SPY003 (long-acting IgG1 antibodies targeting 47, TL1A, and IL-23 respectively) both as monotherapies and in combinations for moderate to severe UC is currently undergoing
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