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Statins, ACE inhibitors, and the majority of cancer chemotherapies were advanced through pharmacologic and clinical reasoning rather than Mendelian genetics

The STEP (Semaglutide Treatment Effect in People with obesity) trials provide comprehensive evidence for semaglutide's lipid effects, while the SURMOUNT trials establish similar benefits for tirzepatide

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The 12mg dose, which produced the greatest weight loss, also showed the most pronounced cardiovascular benefits