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Losing access to these medications would also be catastrophic for many patients with chronic illnesses such as ME/CFS, cancer, Lyme disease, anemia, multiple sclerosis, Crohns disease, and CIRS who have come to depend on these substances for quality of life and disease management

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The discrepancies between experiment and theory throughout the long history of vitamin B12 research are caused by the significant influence of the pseudo-Jahn-Teller effect on its biochemical processes, which cannot be accounted for by either the standard density functional theory (DFT) method [88] or the QM-DFT approximation used in most quantum mechanics/molecular mechanics (QM/MM) studies [2, 89]