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Evaluations of the pharmacokinetics and pharmacodynamics have shown that glargine has a long duration of action and predictable blood glucose-lowering ability in diabetic cats.7 Start newly diagnosed diabetic cats on glargine at 0.5 U/kg subcutaneously every 12 hours and hospitalize them for the first two or three days of therapy.8 Perform daily blood glucose curves and obtain blood samples every four hours during hospitalization