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Poria cocos acidic polysaccharides (PCAP) significantly reduced the mRNA and protein expression levels of NLRP3, ASC, caspase-1, IL-1, and IL-18 in the prefrontal cortex of rats in a chronic unpredictable stress model ( Gastrodia elata polysaccharides (GEP) exhibited the ability to attenuate the relative mRNA expression of pro-inflammatory cytokines TNF- and IL-1 in hippocampal tissues of depressed mice, thereby exerting a neuroprotective effect and ameliorating LPS-induced depressive-like behaviors in mice (Liu et al., 2021)

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