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Phase 1 and Early Development Phase 1 studies in healthy volunteers established proof-of-concept, demonstrating that retatrutide was well-tolerated and produced dose-dependent effects on appetite, food intake, and body weight with acceptable safety profiles

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29 In keeping with this, the GLP-1 mimetics exendin-4 and liraglutide improve trabecular bone microarchitecture and reduce osteoclast activity in ovariectomised (OVX) mice

the main pathways differing between the FI group and the GSH group were Autophagy-other, ErbB signaling pathway, MAPK signaling pathway, and glycerophospholipids metabolism