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GSTs interact with several factors, such as regulatory kinases, and modulate numerous pathways involved in cell proliferation, differentiation and death

It has a significant supportive role suppressing melanin synthesis from within the cell, which reduces the reactivation that makes melasma so resistant to standalone surface treatments

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In addition, it has been claimed to promote new vessel formation (28), upregulation of the growth factors, as well as influencing other local factors (46, 47)