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Plasma PGA levels, reflecting glutathione (GSH) metabolic homeostasis, were analysed in three groups represented by: healthy controls with the wild-type TTR genotype, asymptomatic carriers of the TTR-V30M mutation, and symptomatic patients with TTR-V30M amyloidosis

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Next, we generated quiescent VICs (qVICs) to determine whether the initial phenotype of the cells impacts the response to TMAO