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Some animals presenting with heart failure for the 1st time may have severe clinical signs requiring aggressive therapy (eg, with additional afterload reducers or temporary ventilatory assistance) that more typically would be reserved for those with refractory disease (see Stage D)

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Puerarin Inhibits Fundc1-Mediated Mitochondrial Autophagy and Cse-Induced Apoptosis of Human Bronchial Epithelial Cells by Activating the Pi3k/Akt/Mtor Signaling Pathway