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In addition, Cu2+ triggered the Fenton reaction to generate ROS, and SF consumed GSH in cells, thus promoting redox stress and amplifying the effect of Cu2+

Stimulatory signals: GHRH from hypothalamus (primary stimulator), ghrelin from stomach, deep sleep, exercise, fasting/low blood glucose, certain amino acids

has served on scientific advisory panels and/or speaker's bureaus and served as a consultant to and/or received research support from Amgen, AstraZeneca, Boehringer Ingelheim, Eli Lilly, Fractyl, Gubra, Merck Sharp & Dohme, Novo Nordisk, Sanofi and Zealand Pharma