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Among the 115 genes identified by a genome-wide study as being associated with MASLD and T2DM, 55 genes were involved in inflammation and lipid metabolism

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The constitutive engagement of NK cell NKG2D by endothelial cell Rae-1 led to NKG2D downregulation and diminished NK cell responses (116)

The SURMOUNT-1 trial (N=2,539), which evaluated tirzepatide 5, 10, and 15 mg, reported cholelithiasis in 1.6% of the tirzepatide arm versus 0.5% with placebo over 72 weeks