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Nrf2 Pathway Activation Glutathione depletion triggers activation of Nrf2 (nuclear factor erythroid 2-related factor 2), the master transcription factor for antioxidant gene expression
Astrocyte epigenomics and heterogeneity Astrocytes are also heterogenous by brain region and physiological or pathological conditions, showing transcriptional, morphological, and physiological heterogeneity, as already described
36 Moreover, GLP-1 RAs improve lipid profiles by decreasing serum cholesterol and triglyceride levels and increasing high-density lipoprotein (HDL) levels contributing to cardiovascular protection
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