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After a treatment period of 3 months, to test the effectiveness of treatment as part of usual clinical care, vitamin B12 levels, activity meter, and questionnaires were repeated
Morphologically, ferroptosis is marked by a decrease or disappearance of mitochondrial crests, rupture and contraction of the outer mitochondrial membrane, and shrinkage and darkening of the volume and color of the mitochondria, but the morphological changes in the nucleus are not obvious ( c GSH-GPX4 antioxidant axis, the upstream regulator system x c - is inhibited, and the cystine transport pathway is blocked, resulting in a reduction in cystine transfer and cysteine reduced by NADPH ( Main regulator of ferroptosis GPX4 Since Scott J