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Chen Y, Chen B, Wu T et al (2023) Cryo-EM structure of human -opioid receptor-Gi complex bound to an endogenous agonist dynorphin A

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In addition to immune cells, the HRH2 gene is expressed in gastric parietal cells where the receptor plays a critical role in the regulation of gastric acid production in response to histamine

Clinical trials that successfully reduce these abnormal protein deposits have demonstrated only modest disease-modifying effects (6, 7) highlighting the continued need for additional therapeutic approaches to prevent, slow and treat AD