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As for pharmacological studies, DNIs are sourced from pharmacokinetic data from studies with mostly small numbers of subjects, focusing only on the clinical relevance of the interaction, with some focusing on the mechanism behind the interaction

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Statistical values for ototoxin were omitted from figure legends because it is established that they cause a dose-dependent decrease in hair cell survival, in other words, we know that a dose-response curve for neomycin only will be statistically significant