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Affecting nearly half of individuals with BD, MetS compounds the risk of cardiovascular disease, type 2 diabetes, and premature mortality, while also undermining psychiatric stability and cognitive functioning

Lieu CJ, Tran HT, Fiorentino S, Jiang Z, Mao M, Overman MJ, Eng C, Ellis LM, Heymach J, Kopetz S

While chromium is typically well-tolerated, there have been rare reports of kidney problems with those taking large amounts of chromium supplements

While PAP may be beneficial in a subset of patients with OSA, emerging preclinical and clinical data suggest it may potentially cause harm in others [27], particularly at higher pressures [28], though this requires rigorous validation in future studies