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All surgical experiments were approved by the Chonbuk National University Animal Ethical Care and Use Committee (CBNU-2018-112)

The diagrams in a , d and h were created using BioRender

While familial AD, a less prevalent form, is driven by genetic mutations affecting $A\beta$ metabolism, most sporadic AD cases are attributed to inefficient A clearance (76) (Figure 2)

172 At the cellular level, mTORC1 functions as a nutrient sensor, coordinating the equilibrium between anabolism and catabolism in response to external conditions