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These domains play the major role in binding of JAKs to the cytoplasmic tails of their cognate cytokine receptors (6163)

Sirtuin Activation: NAD+ is the obligate co-substrate for all seven sirtuin deacylases (SIRT17)

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These data suggest that structure and sequence determine which lysine acetylation sites are accessible for enzymatic deacetylation, supporting earlier findings of our laboratory 64