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The impact we are seeing in OA might be real, but we have to define it more clearly. Although no data are conclusive yet, preclinical studies have shown that GLP-1 receptor agonists can inhibit the NF-kB pathway, a key pathway involved in inflammation and cartilage destruction, according to Lane

Therefore, it is a drug that can be expected to help control blood sugar, suppress appetite, and support weight loss

The primary GLP-1 action in rodents' bone is to promote bone formation by stimulating osteoblasts through the regulation of runt-related transcription factor 2 (RUNX2), alkaline phosphatase, collagen type 1, and osteocalcin [55]

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