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RTOCC: Relative TOCC referred to sulfur dioxide

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2,10,22,23 Elevated mitotic activity (Z2 mitotic figures/10 hpf) is the only widely accepted prognostic factor associated with higher tumor aggressiveness and the potential of metastasis

Isothiocyanates likely inhibit the expression and function of hypoxia inducible factors (HIFs) that control angiogenesis, as reported in endothelial cells and malignant cell lines (35)