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Activation of GIP receptors and GLP-1 remains a focus of research due to their involvement in glucose-dependent insulin secretion, modulation of glucagon secretion, regulation of gastric emptying and mechanisms related to the control of satiety and energy intake

In summary, fixed ratio combination of GLP-1RA and basal insulin are potentially helpful tools for the treatment of patients with T2DM as a result of its favorable safety and efficacy profile, particularly in patients who are overweight and uncontrolled on OADs or basal insulin

Both endogenous and exogenous forms of vit-D are inactive and require two successive hydroxylation steps by cytochrome P450 (CYP) enzymes to form fully active vit-D

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