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However, GLP-1 receptor agonists are not recommended if you: - Are pregnant - Are hypersensitive to GLP-1 - Have severe gastrointestinal conditions like inflammatory bowel disease (IBD) - Are at a higher risk of certain thyroid cancers If you have a history of pancreatitis, kidney failure, or gallbladder disease, GLP-1 receptor agonists may not be safe for you

Media and cells were harvested for the GLP-1 secretion assay and gene expression analysis

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Previous study have established that advanced maternal age have altered expression of genes involved in mitochondrial metabolic pathways in granulosa and cumulus cells compared with young 38,39