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Features may include: Involvement of nail fold (Hutchinson sign) and hyponychium, often with parallel furrow pattern or a variant Variation in the width of the longitudinal pigmented band, often triangular Black dots Thinning and fissuring of the nail plate Fading and disappearance of pigmentation Malignant melanoma Melanoma should be considered if pigmentation affects a single nail, especially if it is of recent origin in an adult

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However, oral bioavailability is significantly lower than injectable, and absorption depends heavily on an empty stomach