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In a 2022 analysis looking at GLP-1 users over 12 to 24 months, around 45 percent had already discontinued treatment at one year and nearly 65 percent by two years, and only a minority achieved at least 5 percent weight loss at each time point

Other key hormones like DHEA, estrogen, cortisol, and thyroid hormones can also become too high or too low and play a role in everything from libido and performance to mood and energy levels

10.1152/ajprenal.00104.2006 [DOI] [PubMed] [Google Scholar] 277.Wang, Q