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NNMT has been explored as a target in obesity, insulin resistance, and age-related metabolic decline, supporting the rationale for translational research into body composition and performance contexts (Kannt & Pfenninger, Frontiers in Physiology )

Challenges and Future Directions While the preliminary results of 5-Amino-1MQ are promising, its essential to acknowledge that the journey from preclinical studies to human applications is complex

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