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Potential risks include growth hormone's counter-regulatory effects on glucose metabolism that may oppose tirzepatide's benefits, additive gastrointestinal symptoms, and growth hormone-related adverse effects such as edema and joint pain

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Decreasing plasma glucose to 23 mM or increasing to 15 mM resulted in brain glucose levels of 0.16 mM and 4.5 mM, respectively [67, 72]

This expression is inversely correlated with aging (Chen et al