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Dr Holla said, GLP-1 is usually for people with a BMI over 30, or over 27 if they also have diabetes, high blood pressure, or sleep apnea

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At any given time, each site is at a different stage in the reaction: One site is binding ADP and phosphate One site is catalysing the condensation of ADP and phosphate, and expelling and water One site is expelling ATP, ready to accept ADP and phosphate As protons enter through the stalk of the primary particle that spans the crista membrane, so they cause a rotation of the central part of the ATP synthetase, forcing each site in turn to proceed to the next step in the reaction