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Healthcare providers are encouraged to report any unexpected adverse events through the FDA MedWatch program (www.fda.gov/medwatch or 1-800-FDA-1088) to contribute to the collective understanding of tirzepatide's safety

post-hoc factorial analysis showed body fat mass differed by -4.0% versus placebo (P=0.002), waist circumference dropped by 2.4 cm more than placebo, and daily energy intake was reduced by approximately 300 kcal compared to placebo

A: People with a personal or family history of MTC or MEN2 , prior pancreatitis , certain gallbladder or severe GI disorders, and those pregnant/breastfeeding should avoid or use only with specialist guidance

Science 341 , 278281 (2013)