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Revisiting Tumors and the Cardiovascular System: Mechanistic Intersections and Divergences in Ferroptosis

This has prompted the exploration of novel molecular strategies, including the use of peptides as therapeutic agents [49-53]

These mechanisms do not act independently but form an integrated regulatory network, with SIRT1 positioned centrally within the metabolismimmuneorgan axis. In processes including energy sensing, transcriptional control, redox balance, and cell fate determination, SIRT1 consistently occupies a central or upstream role in signal coordination, capable of orchestrating multiple pathways

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