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and the IC 25 values (25 mg/mL) for IL-5 were 30.2, 263.0, 123.2, and 100.0, respectively, The pharmacological actions of ASHMI (4.5 mg/ mouse twice daily) in early and late-phase airway responses elucidated broad effects on pathological mechanisms impeding the allergic airway response, characterized by reductions in histamine, leukotriene C4, sIgE, BALF eosinophil count, airway remodeling, and Th2 cytokine secretion by BALF and splenocyte cultures [104]

J Clin Investig 126(3):837853 Khanna S, Biswas S, Shang Y, Collard E, Azad A, Kauh C, Bhasker V, Gordillo GM, Sen CK, Roy S (2010) Macrophage dysfunction impairs resolution of inflammation in the wounds of diabetic mice