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The fundamental attributes of hydrogels lie in their three-dimensional hydrophilic polymer networks, which exhibit biocompatibility, biodegradability, and high drug-loading capacity, enabling on-demand drug release in response to environmental stimuli (e.g., pH and temperature) ( 4.3.4 Microneedle delivery systems Microneedles represent a minimally invasive drug delivery platform composed of microscale needles (height: 102000 m

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