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Women with PCOS may experience a decline or halt to ovulation, increased testosterone levels, and insulin resistance, leading to metabolic dysfunction and cardiometabolic disease

Alternatives and Personalized Approaches to GLP-1 Therapy If depression or mood instability emerges during semaglutide treatment, options include dose reduction, switching to a different GLP-1 medication with different pharmacokinetics, or temporarily pausing therapy while addressing the underlying mood disorder with psychiatric support

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