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Spike protein induces proteolytic activation of ENaC Activation of ENaC occurs when the constitutive inhibitory activity of CFTR is lost, and sodium conductance is activated by proteolytic cleavage of the and chains of the heterotrimeric ENaC channel 9,13,14

Interestingly, chronic activation of the immune-inflammatory pathways could play a possible role in HPA axis hypofunction (Papadopoulos and Cleare 2012)

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