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Quick Answer: Tirzepatide commonly causes bowel changes including diarrhea (12-18%) and constipation (6-16%) by slowing gastric emptying and altering gut motility throughout the digestive tract

More specifically, NRF2 and KEAP1 have been analyzed in postmortem motor cortex and spinal cord specimens from ALS patients and a reduction in both NFE2L2 mRNA and NRF2 protein has been found in ALS patient tissues when compared to control ones