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No significant alterations to mitochondrial mass were demonstrated following metformin treatment in HCT116 cells, however, in SW837 cells, mitochondrial mass was significantly increased following 24 h treatment with metformin (10 mM), when compared to control ( Figure 1C )

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If we or any of our third-party manufacturers encounter such difficulties, our ability to provide supply of our product candidates for clinical trials, our ability to obtain marketing approval, or our ability to provide patients supply of our products, if approved, could be delayed or stopped