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At a physical level, these include anemia, exhaustion, loss of appetite, nerve pain, muscle tremor, coordination disorders, and tingling or a sense of numbness in the legs

When it becomes overactive, it essentially tells your cells to store more fat and burn less energy, while also depleting your valuable NAD+ reserves

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Although there is a relationship between low vitamin B12 levels and cognitive decline, clinical studiesincluding those involving people with Alzheimers diseasehave not shown improvement in cognitive function, even doses of the vitamin as high as 1000 micrograms, says Dr