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Although NAC co-exposure was not able to compensate for THC-induced GABA reductions, it normalized relative DA content, spontaneous EPSCs frequency, gamma power and behavioural abnormalities, underscoring the relevance of excitation/inhibition balance and its sensitivity to oxidative stress in these phenomena

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These features need specific energy requirements, resulting in a metabolism reprogramming characterized by elevated OXPHOS, GSH production, and ROS scavenging [138,202]