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In contrast to our results, the authors demonstrated an increase in ECAR within the first hour following in vitro LPS addition and interpreted this as indicative of a switch from oxidative phosphorylation to increased glycolysis as part of the M1 macrophage response following LPS stimulation (51)

To date there are no data on the impact of this type of drug on the reproductive male system, however studies in PCOS women with licogliflozin, a dual SGLT1/2 inhibitor, showed an amelioration of hyperinsulinmeia and hyperandrogenism, but not of T levels, without any effect on body weight (58)