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doi:10.1016/S0140-6736(22)02033-5 Coskun T, Urva S, Roell WC, et al

The Science Behind Dual Agonist Design Creating tirzepatide required sophisticated pharmaceutical engineering to activate both receptors effectively

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"So it's very challenging," Yacawych says, "to be able to separate these side effects, like nausea, from GLP-1's intended effects, like weight loss." A possible workaround came from a team led by Ernie Blevins of the University of Washington