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Treatment initiation typically follows a titration schedule: Patients begin with a low starting dose to minimise gastrointestinal side effects The dose is gradually increased over several weeks to months Titration continues until the therapeutic dose is reached or side effects become limiting Regular review appointments assess tolerability and efficacy Different GLP-1 receptor agonists have varying dosing schedulessome require daily injections or tablets, whilst others are administered weekly

Likely secondary to increased NAD+-dependent mitochondrial activity

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