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Ann Afr Med 2019;18:1216

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Differences in relative proportions between Xenium and scRNA-seq data were most likely technical artefacts: scRNA-seq used whole-thickness tissue dissociation, which can skew cell proportions 59,60,61,62,63 , whereas Xenium captured a fixed 5-m cross-section preserving near-native proportions within the image plane, but are dependent upon the plane of tissue observed