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Recent research has shown that the GLUD1 inhibitor purpurogallin analog R162 may have inhibitory effects on the growth of glioblastoma, non-small cell lung cancer, and breast cancer cells in vitro and in animal models [111]

356,357 Ammonium crosses the blood-brain barrier with ease (in gaseous NH 3 form), and in this manner liver failure causes its massive increase in the brain

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