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For instance, the brain energy consumption accounts for over 20% of the total in order to coordinate with neural activities [6,7,8] and the skeletal muscles can quickly activate metabolic pathways for ATP synthesis during exercise [9]

Long term use does not cause progressive worsening

95% CI, 0.27 to 0.26), while heterogeneity remained high for both subgroups (75% and 65%, respectively)

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