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Preclinical studies demonstrated that sildenafil attenuated cardiomyocyte apoptosis, improved left ventricular function, and increased survival in doxorubicin-treated mice [184]

Bioinformatics and multi-omics approaches are pivotal in uncovering the complex pathophysiological mechanisms of DN, facilitating novel therapeutic targets

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Hansen, CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide