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Furthermore, energy stress can activate adenosine-monophosphate-activated protein kinase (AMPK), which, in turn, controls acetyl-CoA carboxylase, ultimately limiting PUFA production and reducing the susceptibility to ferroptosis (28) ( Figure 1 )

The active ingredient, silibinin, is present in varying amounts, solubilities, and oral bioavailabilities in commercially available silymarin preparations (Zhu et al., 2013)