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This study demonstrates, through real-time live cell metabolic profiling and transcriptomic profiling, that metformin significantly alters energy metabolism in both in vitro and ex vivo models of rectal adenocarcinoma and importantly, radiosensitises radioresistant rectal cancer cells to clinically-relevant doses of X-ray radiation

Risks may include joint pain, insulin resistance in some contexts, edema, carpal tunneltype symptoms, and potential tumor promotion in those with existing malignancies, which is why medical screening is important

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