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By conducting RNA-seq analysis, SOD activity and malondialdehyde assays in ovaries, as well as ROS staining in oocytes, we revealed that the semaglutide treatment reduced the elevated oxidative stress in ovaries and high ROS levels in oocytes from PPO mice, possibly through activating the PI3K/AKT pathway and improving the state of SOD

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This is an important discovery that identified the long-sought-after incretin (an intestine-secreted hormone that triggers insulin release) and led to its application as an anti-diabetic strategy