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To view digital features for this article, go to Introduction Diabetes care is evolving towards the personalized medicine approach, moving beyond the basic assumption that diabetes is solely a consequence of -cell dysfunction in a single hormone, insulin [1,2,3,4]

The molecule consists of a modified GLP-1 analog, containing three key amino acid substitutions: Ala8Gly, Gly22Glu, and Arg36Gly, covalently fused to the Fc (constant) region of human immunoglobulin G subclass 4 (IgG4) (Fig

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doi: 10.1002/(SICI)1521-4141(199912)29:12 3.0.CO;2-#